Women with elevated homocysteine and low serum folate concentrations are at greater risk for recurrent spontaneous early miscarriages, according to researchers in the Netherlands. In a recent European study, researchers measured homocysteine and blood folate levels in 123 women who had had at least two consecutive spontaneous miscarriages. Compared with controls, women with recurrent miscarriages had significantly lower serum folate concentrations. The study found that the risk was even greater for women who had never had a pregnancy longer than 16 weeks and for those who had had three or more miscarriages. The authors point out that women in the study were not receiving folic acid supplementation, and they suggest that supplementation might be beneficial in women who have had early miscarriages.
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