Vegan diet eases hot flashes through gut microbiome

November 30, 2023 in Healthy Eating, Menopause, Nutrition Topics in the News, Women's Health

Vegan diet eases hot flashes through gut microbiome

A low-fat vegan diet that includes soy fosters changes in the gut microbiome that decrease postmenopausal hot flashes overall by 95%, according to a new study by the Physicians Committee for Responsible Medicine.

A vegan diet eliminated severe hot flashes, led to a 96% decrease in moderate-to-severe hot flashes, and reduced daytime and nighttime hot flashes by 96% and 94%, respectively. Participants also lost 6.4 pounds on average.

About the study

The new research is a secondary analysis of the WAVS trial—the Women’s Study for the Alleviation of Vasomotor Symptoms—that the Physicians Committee previously published in the journal Menopause. In the study, 84 postmenopausal women reporting two or more moderate-to-severe hot flashes daily were randomly assigned to either the low-fat vegan diet group (which included a half cup cooked soybeans a day) or to the control group that continued their usual diets for 12 weeks.

Stool samples were collected from a subset of 11 participants and were used to perform a gut microbiome analysis at baseline and after 12 weeks on a vegan diet.

Alterations in gut bacteria

Changes in the amount of several families, genera and species of bacteria were found.

The study is the first to find that reductions in the abundance of Porphyromonas and Prevotella corporis are associated with the reduction in severe day hot flashes. Prevotella corporis has also been found in the gut of people with rheumatoid arthritis and seems to have inflammatory properties.

The decrease in the abundance of Clostridium asparagiforme was associated with a reduction in total severe and severe night hot flashes. Clostridium asparagiforme has also been found to produce trimethylamine-N-oxide, a compound associated with an increased risk of cardiovascular disease and type 2 diabetes.

Decreased abundance of Clostridium asparagiforme may partially explain the beneficial effects of a plant-based diet on cardiovascular health and provide a possible link between hot flashes and cardiovascular disease.

Changes in the abundance of other bacteria looked at in the study may play a role in alleviating hot flashes by stabilizing estrogen levels, reducing inflammation, and increasing satiety among other benefits.

Larger randomized clinical trials are needed to further investigate these findings.

Source: Complementary Therapies in Medicine, November 8, 2023

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