Dietary levels of nutritional factors related to homocysteine metabolism reduce the risk of dying from heart disease, according to research conducted in Spain. Average dietary intakes of folate, vitamin B-6 and vitamin B-12 varied widely by province. The investigators analyzed the association between provincial diet and cardiovascular death between 1990 and 1994 for persons aged 35 to 84 years.
Death rates for both heart diseases were lower in men and women in provinces where diets were richer in folate. The investigators note that this association was unaffected by such factors as socioeconomic level, heart disease risk, or use of vitamin supplements. Death due to heart disease was also reduced in provinces with higher intake of vitamin B-12. The investigators also observed a trend suggesting a protective effect of vitamin B-6.
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