A new study conducted by researchers from the University of Washington and the National University of Natural Medicine investigated how diet influences epigenetic, or biological, aging.
They found that certain plant-based foods containing natural compounds called methyl adaptogens were associated with a decrease in epigenetic age. This effect was measured using DNA methylation, a marker that reflects how the body ages at the cellular level.
The findings suggest that targeted food choices may help slow the aging process.
What is epigenic age?
Epigenetic age refers to how old a person’s cells appear biologically, rather than their chronological age in years.
DNA methylation patterns, which are chemical tags on DNA, can indicate whether someone is aging faster or slower than expected.
About the study
For the latest research, researchers used Horvath’s epigenetic clock, a widely accepted tool to measure changes in epigenetic age.
The analysis included healthy men aged 50 to 72 who had previously completed an eight-week program featuring a plant-based, nutrient-rich diet, along with guidance on exercise, sleep and stress management.
Researchers focused on individual dietary differences to understand why some participants experienced greater improvements in epigenetic age than others.
The findings
The study found that those who ate higher amounts of “methyl adaptogen foods”—including turmeric, rosemary, garlic, berries, green tea and oolong tea—experienced greater reductions in epigenetic age.
These benefits remained significant even after accounting for weight changes and participants’ starting epigenetic age, suggesting that the foods themselves had a direct impact on aging markers.
Natural compounds in methyl adaptogen foods are known to influence how genes behave by affecting DNA methylation. Previous studies have shown that these compounds may support healthy aging and help lower the risk of conditions such as heart disease and cognitive decline.
While this study involved only 43 middle-aged U.S. men, it adds knowledge to growing research showing that diets rich in polyphenols—found in vegetables, fruits, and teas—are associated with slower aging.
These findings support earlier results from studies on Mediterranean and traditional Japanese diets, both known for their health benefits.
Future research need to include larger and more diverse populations and use updated epigenetic aging tools to confirm these results.
The findings highlight a practical, food-based strategy that may help reduce epigenetic aging and support long-term health.
Source: Aging, April 17, 2025.
All research on this web site is the property of Leslie Beck Nutrition Consulting Inc. and is protected by copyright. Keep in mind that research on these matters continues daily and is subject to change. The information presented is not intended as a substitute for medical treatment. It is intended to provide ongoing support of your healthy lifestyle practices.