Researchers at the University of Nottingham report that combining specific dietary supplements may provide stronger immune and metabolic support than taking prebiotics or omega 3 alone. The findings suggest this paired approach could help lower the risk of diseases associated with long term inflammation.
About the study
The study compared three popular supplements: omega-3 fatty acids, fibre and a prebiotic-fibre blend (defined as a synbiotic).
Along with fibre, the synbiotic supplement contained a mix of naturally occurring probiotic bacteria and yeasts created during the traditional fermentation of goat's milk with live kefir grains. These grains are living cultures that contain dozens of beneficial microbial species.
Over the course of six weeks, healthy adults who took the synbiotic supplement experienced the greatest reduction in systemic inflammatory proteins compared with those who took an omega 3 or fibre supplement by itself.
Systemic inflammatory markers in the bloodstream reflect inflammation occurring throughout the body rather than in just one area.
Participants in the synbiotic group showed lower overall inflammation levels, pointing to improved immune balance and a potentially reduced risk of chronic inflammation related conditions (like heart disease or other metabolic conditions).
The results indicate that combining probiotics and prebiotics may support immune and metabolic health more effectively than single ingredient supplements.
Kefir and prebiotic fibres work together
When kefir, which is rich in live microbes, is paired with prebiotic fibre, the result is a synbiotic effect. The fibre serves as food for the beneficial bacteria, allowing them to grow and generate helpful compounds such as short chain fatty acids such as butyrate. Butyrate is known for its anti-inflammatory and immune regulating effects throughout the body.
Future research will examine how these supplements perform in people who already have specific health conditions to better understand their potential benefits.
Source: Journal of Translational Medicine, October 16, 2025.
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